Using a spacer with a fluticasone inhaler decreases the risk of which adverse effect?

Using a spacer with a fluticasone inhaler effectively reduces the risk of oral candidiasis, which is a fungal infection caused by Candida species occurring in the mouth and throat. Fluticasone is a corticosteroid that can suppress local immune responses when inhaled, making the oral cavity more susceptible to such infections.

When a spacer is used, it allows for better distribution and deposition of the medication into the lungs rather than in the mouth and throat. This minimizes the amount of fluticasone that comes in direct contact with the oral mucosa, thereby reducing the likelihood of developing oral candidiasis. The proper use of spacers promotes more effective drug delivery while also helping to mitigate local side effects associated with inhaled corticosteroids.