Which adverse effect should be included in the teaching for a client starting tamoxifen for breast cancer?

Tamoxifen is a selective estrogen receptor modulator commonly used in the treatment and prevention of breast cancer. One of the notable adverse effects associated with tamoxifen therapy is hot flashes. This occurs because tamoxifen works by blocking estrogen receptors in breast tissue, which can lead to a decrease in estrogenic stimulation. Since estrogen plays a key role in regulating body temperature, its blockade can result in vasomotor symptoms, such as hot flashes.

Clients beginning tamoxifen should be made aware of this potential effect, as it can significantly impact their quality of life. Understanding this side effect allows for better management strategies, such as lifestyle modifications or discussing symptomatic therapies if needed.

Additionally, other side effects, such as urinary retention, constipation, and bradycardia, are less commonly associated with tamoxifen and may not be relevant in the context of patient education regarding the most expected adverse effects of the drug. Therefore, highlighting hot flashes is essential to prepare clients for the changes they may experience during treatment.